SSD longevity seems to be better than HDDs overall. The limiting factor is how many write cycles the SSD can handle, but in most cases the write endurance is so high that it’s unreachable by most home/NAS systems.
SSDs are however really bad for cold storage, as they will lose the charge stored in their cells if left unpowered too long. When the SSD is powered it will automatically refresh the cells in the background to ensure they don’t lose their charge.
ZFS doesn’t really support mismatched disks. In OP’s case it would behave as if it was 4x 2TB disks, making 4 TB of raw storage unusable, with 1 disk of parity that would yield 6TB of usable storage. In the future the 2x 2TB disks could be swapped with 4 TB disks, and then ZFS would make use of all the storage, yielding 12 TB of usable storage.
BTRFS handles mismatched disks just fine, however it’s RAID5 and RAID6 modes are still partially broken. RAID1 works fine, but results in half the storage being used for parity, so this would again yield a total of 6TB usable with the current disks.