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If a system is poorly understood, then by definition it cannot be factored into predictions. When we say something is “unlikely” we mean “it is unlikely based on what we understand”. I don’t think it’s very useful to ask, “Well, is it unlikely based on what we don’t understand?”, because that’s not a question that can be answered.
Is a catastrophic, world-ending feedback loop likely based on what we understand? The IPCC reports paint a grim future, but I don’t believe any has suggested that it’s likely the entire Earth will be rendered completely uninhabitable to human life.